Stocks Making the Biggest Moves Midday: Nvidia, Ultragenyx Pharmaceutical, Newmont, DigitalBridge, and More
Published: December 29, 2025 | Updated: 2:24 PM EST
By Sarah Min and Darla Mercado, CFP®
As the trading day reached its midpoint on Monday, several stocks stood out with significant price movements amid mixed market conditions. Here’s a breakdown of some of the most notable shifts:
Ultragenyx Pharmaceutical Plunges After Clinical Trial Disappointment
Shares of Ultragenyx Pharmaceutical plunged more than 40% following the company’s announcement that its bone disease drug, setrusumab, did not meet expectations in two pivotal clinical trials. According to a company statement, “Neither study achieved its primary endpoint of reduction in annualized clinical fracture rate compared to placebo or bisphosphonates.” The setback dealt a heavy blow to investor confidence in the biopharma firm.
Miners Decline Alongside Falling Gold and Silver Prices
The mining sector experienced pressure as precious metal prices dropped sharply. Shares of Newmont fell over 5%, while Freeport-McMoRan slid approximately 2%. Reflecting the sector’s weakness, the Global X Silver Miners ETF (SIL) also declined by more than 4%. Silver prices, which surged above $80 per ounce overnight, declined by more than 7%, and gold prices dropped over 4% during Monday’s session.
Energy Stocks Gain on Rising Oil Prices and Geopolitical Hopes
Energy stocks enjoyed gains amid a rise in oil prices, which increased by more than 2%. Investors speculated about the potential for peace talks in Ukraine combined with concerns about possible supply disruptions in the Middle East. Diamondback Energy and Devon Energy surged nearly 2% each, with the energy sector emerging as the top performer within the S&P 500 index.
DigitalBridge Surges Following Acquisition Announcement
DigitalBridge, a private equity firm specializing in investments in data centers and digital infrastructure, jumped 10% after Japan’s SoftBank announced an agreement to acquire the company for approximately $4 billion. The deal highlights SoftBank’s strategic focus on expanding its presence in digital infrastructure assets.
Nvidia Shares Slip After Record AI Chip Acquisition
Tech giant Nvidia saw its stock dip nearly 2% in early trading, pulling back some of last week’s gains. Last week, Nvidia’s shares had risen 5.3% following news that the company would acquire AI chip startup Groq’s assets in its largest-ever deal, reportedly valued at around $20 billion. The modest retreat on Monday suggests some investor profit-taking following the large transaction announcement.
Praxis Precision Medicines Rockets on Positive Outlook
Shares of Praxis Precision Medicines, a clinical-stage biopharmaceutical company, surged 13% after investment firm BTIG named it a top stock pick for 2026. BTIG also raised its price target for Praxis to $843 per share, up from $507, signaling a potential upside of over 213% from current levels.
AXT Declines on New Share Offering
Semiconductor component manufacturer AXT saw its shares drop nearly 4% after it disclosed plans to issue over 7 million new shares through a public offering. The shares are priced at $12.25 each, collectively valued at about $87 million. The capital raise is intended to support the company’s growth and operational needs.
Market Snapshot
- Ultragenyx Pharmaceutical: -40%
- Newmont: -5%
- Freeport-McMoRan: -2%
- Global X Silver Miners ETF (SIL): -4%
- Diamondback Energy: +2%
- Devon Energy: +2%
- DigitalBridge: +10%
- Nvidia: -2%
- Praxis Precision Medicines: +13%
- AXT: -4%
Investors should continue to monitor developments in clinical trial outcomes, commodity price fluctuations, and geopolitical events that may influence market dynamics as the year comes to a close.
— Reporting by Sarah Min; additional contributions by Liz Napolitano for CNBC.
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